Had this bug too. My sim Arianna and her daughter Melodi would start running EVERYWHERE, after her husband played tag with Melodi (my memory is so bad, I can't remember whether the husband was affected or not! I don't care so much for him, anyway...
). But it did disappear after a few sim days, without travelling or evicting them.
They live in Sunset valley (have all lived there their whole lives) and I have the latest patch, but not Ambitions, so it's the patch that does it. I don't remember them playing tag since after the running bug disappeared, but I'll have to see if a game of tag will set it off again in the future.
And I've got no mods or CC (never have, and not sure if I ever will), but I think we're all already agreeing that it's no third party content that's the problem with this bug.