Well, I started messing around with combos including 1 Life Fruit and 3 Flame Fruit. I'm supposed to be a "Mix Master," so I tried checking the predictions. Most of them have been "won't go well together" or "not bad, but there are better combinations." I'm trying to make the ones that are supposed to "go well together." The first one I did, though, with 6 Plum, came up with a message as it finished being pressed or fermented or whatever that it was terrible! I drank some anyway, just for the heck of it, and I did get all 4 moodlets: +50 Full of Life; +25 Commanding Complexity; +15 Warm Fuzzies; and +15 Sugar Rush.
So, since I certainly don't need the §imoleons, I guess I'll just combine the 1 Life Fruit, 3 Flame Fruit & whatever else I have the most of.