Samoht, I didn't uninstall CC, just run without it, I installed the same I had before, and add some hairstyles and clothes, and few more patterns, nothing big. I'll try uninstalling them too, thanks.
Pam, you got it right, I followed your tutorial for manual uninstall (thank you for that) and cleaned save file from bad files. I saved last 10 different save versions of dynasty game, and cleaned registry, defrag disk (it is done weekly automatically, but I did the manual defrag before install anyway).
I think you're right with big file issue. New game I started after installing stuff packs run great. I traveled a lot without bugs, no crashing at all.
I'll first try to uninstall CC but I will miss those nice hairstyles, and if that doesn't help, I'll wait for Late Night, and do uninstall again, and again install everything, and I'll try starting from earlier saves too, to see if it make a difference. I really want to finish this dynasty. It is my first multigenerational game I played in Sims, and I'm playing them for more than a decade!
Thank you for your advices, I hope some of them will work.
edit: Pam, I tried restarting computer after crash, then load game again, and again, it crash after few minutes. Then I played other game for around 2-3 hours without problem, including big tombs, so I don't think it is graphic issue. Game cache is cleaned with this uninstall, and all bad files are deleted. So I guess I'll just tried earlier saves, and uninstalling CC. Hope it will work