I turned off ITF, since Gen5 (sculptor) wasn't getting any Business opportunities; she finished up the last of her requirements 2 days after hitting elder. All the game did for me is give me the warning that missing objects were replaced by the closest available. I had to redecorate the house, and redo the spouse's wardrobe, but that's it. Biggest issue I ran into since was that people weren't aging up, so I just restarted the game and that fixed it.
I had planned to turn it back on, then turn it off for generation 9, then turn it back on until generation 13, off, then back on at 14. But really, ITF does not (in the end) add too much that I just Can't Live Without, so it'll stay off until generation 15.