I'm on another Macbook Pro, installing via disk, & i have the EP's World Adventures, Ambitions, Late Night and Generations.
I am not familiar with Macs. Sorry. Do you have all the patches installed?
I do not know where your program files are stored but if you can find the TS3EP04.exe file (in the Game\bin folder) you could at least try to start the game that way. One other thing I would suggest is uninstall everything and reinstall one game at a time and try to launch just the one game. If the game works, install your EP's one at a time trying each as you install.
Hopefully someone on the forum who is familiar with your system will see this and can help you better.