I also tried to make the most profitable resort without any cheats. I managed to consistently net $480501/day!
I found that if you build a floor full of towers, you can then build a room around those towers and put another floor of towers on the next floor (even though the models intersect). Note that I'm not using moveobjects.
I also found that adding a bunk bed increased the population by 2 so I crammed in as many as I could in the underground floors.
Like Vinyl, I also put all amenities in the first level basement.
Towers per floor: 12
Floors full of towers: 6
Total towers: 72
Bunk beds per basement floor: 1280
Total basements full of beds: 3
Total Beds: 3840 (I placed all these individually!)
Occupants: 12,724 (Always maxed)
Revenue: $458,064
Expenses: $137,730
Profit after "Hotel Mogul" Lifetime Reward: $480,501