Plan. Plan plan plan.
Always have a backup idea in mind. (Generation 5 was supposed to SuperMax Martial Arts, but I got a stupid glitch with the sparring, so couldn't complete the last skill challenge - so I switched her to Athletics)
Be creative! Look at other stories in progress for ideas on what to do.
Once money is rolling in, don't be afraid to spend it (the Wind household has so much money that, to keep the elders out of my hair, I send them to the spa daily for a Massage, a Manicure/Pedicure/Soak, Facial, Body Treatment, and the $7500 Package).
Make backups. Glitches happen.
This is a weird quirk of mine, but I prefer to save the game first, and then exit the game. I've only ever gotten 1 error while saving by doing that, whereas if I would do the save while quitting method, I was plagued with errors.
If you can do it without failing the Dynasty, work on some achievements during the slow times of the game.