Well I have seen on YouTube there is a ''horror'' spoof of The Sims and it's really funny. So I think a movie maybe about they find out there in a game would be funny.
Wait, that was... College Humor account, right? Or something like that. Yeah, people playing as sims can be very funny indeed. But... I think it's only funny for the insiders, people like you and me who actually play that game.
I don't get WOW humor as I don't play World of Wardcraft but I know people who play that game are laughing out loud seeing funny vids about that game. Can't blame them, though don't get it either.