Practical tip for the babies: put the cribs in a U shape so that the adult doesn't have to walk too far to get to the next one. Also, if there's more than one empty crib and you select "put in crib" on the baby, the adult will generally not put the baby in the empty crib right in front of him/her that the baby was just taken out of, but will walk all the way across the room to the other one. Selecting "Put Baby In Crib" on the crib will always get you the specific crib you're after.
Definitely potty-train the toddlers first - the bladder need doesn't need to be yellow to have a successful training session, and you can use the potty chair twice between empties if it comes down to that. Toddlers are pretty good at entertaining themselves - and even a regular teddy bear can fill a toddler's social need. So can the block table if you have a child or another toddler who can talk in the house.
In general - when I did the Baby Boomer challenge (no baby sitters allowed!) I had the parents sleep at different times, and mostly left the toddlers on their own except when it was time for skill training or feeding. Also, it was sometimes useful to wake a toddler up to work on skills if the parent not on baby duty had a lot of energy.