If you want to try the game without the mods, best thing to do is move your mods folder to your desktop for temporary.
I couldn't live without some of the mods I use. MasterController, Register, Overwatch, Traffic are some of my must-have mods.
If you're anything like me. Try a new test-game first, with mods to see how that works out. If it's still acting odd, then move the mods folder to see if that helps.