I just had this happen to me the other day. Just after starting a new game. I was trying to find a house to put my sim person in. And when I went to move her in to the house, I couldn't. I went to the phone and it said something like no interactions available. I was like huh?! Luckily, I had just saved my game beforehand. I quitted out, and started from the previous save.
So, yes... I'm totally with the - making several saves throughout the gameplay.
MrsFlynn