If your sim tries on that "woohoo" perfume available from skill level zero (I forget the full name). They will vomit constantly for two hours. They don't even try for the toilet. Most of the time my sim puked right outside her front door, but she did also vomit on the floor by her bed.
My sim has the artistic and savvy sculptor traits and gains skill levels exemely quickly. Faster than when she's painting.