My computer's resolution is 1920x1080, which is the largest resolution that the game supports (I believe). Right now, I just switched it to it to 1600x900 and Windowed mode. I'm in edit town mode, and looking down, the graphics look kinda Sims-2-ish. However, I can switch to a window effortelssly, without my computer "loading" anything. The only thing I'm worried about is icons in build and buy mode since those are small enough as-is. However, the interface shouldn't change sizes, so... I'll try and play the game in windowed mode for a day and see what happens.