I am playing on a Mac with Lion installed. I haven't had any problems so far, and though I don't have a PC as well (to compare the two), the advice given for the different aspects of the game seems to work for me. Sometimes in a tech related thread I've noticed people are kind enough to write, "If you're playing on a Mac you'll need to do this instead of that," etc. There is a section for Mac users in the Forum's site map, if I remember correctly.